I'd missed out a little at first, because episode topics often seemed to focus on fundraising, angel investing, or aquisition - 3 things I'm not personally interested in for my small online business. But, having caught up on every episode, I've found it's valuable just to listen to two business owners banter who (a) know from experience what they're talking about and (b) are sensible and not slimy/hustly about it. It's a combination surprisingly rare to find online, and leads to sharing a lot of generally good advice about business relationships, competitive positioning, recent changes in customer acquisition, and clear ways to talk about things likely to affect any business. Topics are consistent enough to form a common thread, but with different enough angles or updated points each time that it doesn't become repetitive. And, though it's not the most important thing about a show, production quality is great right from the start - music, editing, mixing and so on are solid so they never distract from the content.
